Format

Send to

Choose Destination
Nat Cell Biol. 1999 Jun;1(2):113-8.

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.

Author information

1
Department of Biochemistry, University of Geneva, Switzerland.

Abstract

The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann-Pick type C (NPC), and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device. The results also suggest that similar endosomal defects accompany the anti-phospholipid syndrome and NPC.

Comment in

PMID:
10559883
DOI:
10.1038/10084
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center