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Atherosclerosis. 1999 Dec;147(2):243-7.

Influence of serum triglyceride levels on the risk for myocardial infarction in 12,510 middle aged males: interaction with serum cholesterol.

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1
Department of Medicine, Malmö University Hospital, University of Lund, S-205 02, Malmö, Sweden.

Abstract

OBJECTIVE:

To study the influence of different levels of serum (s)-triglycerides in relation to s-cholesterol on the risk of myocardial infarction.

DESIGN AND SUBJECTS:

A 6-13 (mean 10) year follow-up of 12,510 middle-aged men. Fasting s-triglycerides and s-cholesterol were measured at the screening examination.

SETTING:

Section of Preventive Medicine at the Department of Internal Medicine, Malmö General Hospital, an urban hospital for 240,000 inhabitants in southern Sweden.

INTERVENTION:

In minor groups of patients there were interventions addressing high lipid levels, high alcohol consumption, hypertension and glucose intolerance.

MAIN OUTCOME MEASURE:

Myocardial infarction was used as an end-point.

RESULTS:

446 myocardial infarctions occurred. The cumulative incidence rates were for the lowest triglyceride quartile 1.2%, for the second 3.2%, for the third 4.1% and for the highest 5.6%. After adjustment for age, year of screening, body mass index, diabetes, smoking, hypertension and s-cholesterol there was a significant relationship between triglycerides and the relative risk for myocardial infarction (P for trend=0.0087). For increasing levels of triglycerides, adjusted for the above factors except cholesterol, the impact of a certain cholesterol value for the occurrence of myocardial infarction was increased (P for trend=0.0092).

CONCLUSIONS:

The present study emphasizes the interaction between cholesterol and triglyceride values for the risk of myocardial infarction. It is concluded that at triglyceride values above 1.0 mmol/l and cholesterol above 6.8 mmol/l there is an increasing interaction between cholesterol and triglyceride levels that might be of importance when evaluating the cardiovascular risk of middle aged men.

PMID:
10559509
[Indexed for MEDLINE]
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