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J Infect Dis. 1999 Dec;180(6):2018-22.

Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.

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Saint Louis University Health Sciences Center, St. Louis, MO 63110, USA.

Erratum in

  • J Infect Dis 2000 Feb;181(2):814.


A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.

[Indexed for MEDLINE]

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