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Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13427-31.

Running enhances neurogenesis, learning, and long-term potentiation in mice.

Author information

1
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain structure that is important for memory function. Consequently, spatial learning and long-term potentiation (LTP) were tested in groups of mice housed either with a running wheel (runners) or under standard conditions (controls). Mice were injected with bromodeoxyuridine to label dividing cells and trained in the Morris water maze. LTP was studied in the dentate gyrus and area CA1 in hippocampal slices from these mice. Running improved water maze performance, increased bromodeoxyuridine-positive cell numbers, and selectively enhanced dentate gyrus LTP. Our results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.

PMID:
10557337
PMCID:
PMC23964
DOI:
10.1073/pnas.96.23.13427
[Indexed for MEDLINE]
Free PMC Article

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