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J Rheumatol. 1999 Nov;26(11):2344-7.

Thalidomide in the treatment of refractory rheumatoid arthritis.

Author information

1
Department of Medicine, University of Toronto, Centre for Advanced Therapeutics in Arthritis, Mount Sinai Hospital, Ontario, Canada.

Abstract

OBJECTIVE:

To review outcomes in 10 patients with rheumatoid arthritis (RA) treated with thalidomide.

METHODS:

We reviewed our experience with 10 patients treated with thalidomide using a standard therapeutic protocol and standard outcome measures.

RESULTS:

We observed no significant improvement in any outcome measure, likely as a consequence of the limited duration of therapy related to thalidomide toxicity.

CONCLUSION:

Formal studies of the efficacy of thalidomide in RA are required with alternative doses of the compound used by us, or with compounds derived from other sources.

PMID:
10555888
[Indexed for MEDLINE]

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