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J Antimicrob Chemother. 1999 Nov;44(5):705-8.

Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents.

Author information

1
Servicio de Microbiología Clínica y Enfermedades Infecciosas-VIH, Hospital General Universitario 'Gregorio Marañón', Madrid, Spain.

Abstract

We compare a rapid dilution method for the determination of antiviral susceptibility of herpes simplex virus (HSV) with the plaque reduction assay. A total of 84 HSV clinical isolates were studied by both methods to detect in-vitro resistance to acyclovir and foscarnet. The rapid method showed for the detection of HSV isolates resistant to acyclovir and foscarnet, a sensitivity of 96. 8% and 100% and specificity of 100% and 100%, respectively. This method provides an easy and accurate screening procedure for the susceptibility testing of HSV to antiviral agents.

PMID:
10552991
DOI:
10.1093/jac/44.5.705
[Indexed for MEDLINE]

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