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J Clin Virol. 1999 Sep;14(1):67-71.

Genomic analysis of adenovirus isolated from Argentinian children with acute lower respiratory infections.

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1
Centro de Educación Médica e Investigaciones Clínicas N. Quirno, Laboratorio de Virología, Buenos Aires, Argentina.

Abstract

BACKGROUND:

Adenoviruses are the second cause of acute lower respiratory infection (ALRI) of viral origin in small children from Buenos Aires, Argentina.

OBJECTIVE:

The aim of this study was to characterize, by restriction enzyme analysis, 17 adenovirus strains isolated from the nasopharyngeal aspirates of children under 2 years of age hospitalized due to ALRI.

STUDY DESIGN:

Seventeen adenovirus strains isolated between May 1991 and December 1992 in one hospital of Buenos Aires were studied. Adenoviruses were amplified in HEp-2 cells and viral DNA was studied with the restriction enzymes Bam HI and Sma I.

RESULTS AND CONCLUSIONS:

Eighty two percent (14/17) of the isolates were classified as adenoviruses from subgenus b and 17.7% (3/17) belonged to subgenus c. Genome type 7 h was detected in 85.7% (12/14) and 7 i in 14.3% (2/14) of the strains from subgenus b. The case lethality associated with adenovirus genome type 7 was 28.6% (4/14 cases). Three fatal cases corresponded to Ad 7 h and one to Ad 7i. Ad 7h shows a high prevalence in small children hospitalized with ALRI and is associated with a high fatality rate.

PMID:
10548132
[Indexed for MEDLINE]
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