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Semin Cancer Biol. 1999 Oct;9(5):369-75.

DNA methylation and the Epstein-Barr virus.

Author information

1
Department of Oncology, The Johns Hopkins University, School of Medicine, 418 N. Bond St., Baltimore, MD 21231, USA.

Abstract

EBV is a ubiquitous herpesvirus associated with a variety of lymphoid and epithelial tumors. In healthy lymphocytes and in tumors immune surveillance is evaded by suppression of a family of immunodominant viral antigens. Methylation of a viral promoter plays a crucial role in this suppression. Methylation of the viral genome in the latent state over evolutionary time is believed to account for CpG suppression that distinguishes this virus from most other large DNA viruses. Pharmacologic manipulation of methylation may offer an opportunity to unmask viral antigens and expose tumors to immune surveillance.

PMID:
10547345
DOI:
10.1006/scbi.1999.0137
[Indexed for MEDLINE]

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