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Biochem Cell Biol. 1999;77(4):249-55.

Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD).

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Laboratoire de génétique moléculaire, Ecole normale supérieure, Paris, France.


The largest subunit of RNA polymerase II has an intriguing feature in its carboxyl-terminal domain (CTD) that consists of multiple repeats of an evolutionary conserved motif of seven amino acids. CTD phosphorylation plays a pivotal role in controlling mRNA synthesis and maturation. In exponentially growing cells, the phosphate turnover on the CTD is fast; it is blocked by common inhibitors of transcription, such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and actinomycin D. Transcription-independent changes in CTD phosphorylation are observed at critical developmental stages, such as meiosis and early development.

[Indexed for MEDLINE]

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