Format

Send to

Choose Destination
Biophys J. 1999 Nov;77(5):2638-42.

Free Brownian motion of individual lipid molecules in biomembranes.

Author information

1
Institute for Biophysics, University of Linz, Linz, Austria.

Abstract

The mobility of phospholipids in free-standing and supported membranes was investigated on the level of individual molecules. For the analysis of trajectories a new statistical treatment was developed that permitted us to clearly distinguish different types of diffusional motion. A freely diffusing subfraction of lipids within supported membranes was identified. Its mobility was characterized by a mean lateral diffusion constant of D(supp) = 4.6 microm(2)/s. In comparison, the mobility of lipids embedded in "free-standing" planar membranes yielded an increase in the mean diffusion constant by a factor of 4.5, D(free) = 20.6 microm(2)/s. This increase is attributed to the ultrathin (<or=1 nm) lubricating water layer between membranes and glass support.

PMID:
10545363
PMCID:
PMC1300537
DOI:
10.1016/S0006-3495(99)77097-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center