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Structure. 1999 Oct 15;7(10):R225-9.

Caspase 8: igniting the death machine.

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Programs in Cell Death and Aging Research The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California, 92037, USA.


Intense research into the signaling pathways of apoptosis has revealed a dominant role for proteases belonging to the caspase family, which in humans has 11 members at present. Two papers in the September issue of Structure with Folding & Design have for the first time revealed the structure of the key apoptotic initiator, caspase 8.

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