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Mol Cell Biochem. 1999 Sep;199(1-2):125-37.

Poly(ADP-ribosylation) and apoptosis.

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Istituto di Genetica Biochimica ed Evoluzionistica del C.N.R., Pavia, Italy.


Poly(ADP-ribosylation) is a post-translational modification playing a relevant role in DNA damage recovery, DNA replication and viral integration. Several reports also suggest a modulation of this process during cell death by apoptosis. The aim of this review is to discuss the possible involvement of poly(ADP-ribosylation) during apoptosis, by dealing with general considerations on apoptosis, and further examining the correlation between NAD consumption and cell death, the regulation of poly(ADP-ribose) metabolism in apoptotic cells, the effect of poly(ADP-ribose) polymerase inhibition on cell death occurrence and the use of enzyme cleavage as a marker of apoptosis. Finally, the future prospects of the research in this area will be addressed.

[Indexed for MEDLINE]

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