Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 1999 Dec;22(12):561-7.

Long-term potentiation in the amygdala: a mechanism for emotional learning and memory.

Author information

Dept of Psychology and Neuroscience Program, University of Michigan, MI 48109-1109, USA.


In the mammalian brain, LTP is an enduring form of synaptic plasticity that is posited to have a role in learning and memory. Compelling new evidence for this view derives from studies of LTP in the amygdala, a brain structure that is essential for simple forms of emotional learning and memory, such as Pavlovian fear conditioning in rats. More specifically, antagonists of the NMDA receptor block both amygdaloid LTP induction and fear conditioning, fear conditioning induces increases in amygdaloid synaptic transmission that resemble LTP, and genetic modifications that disrupt amygdaloid LTP eliminate fear conditioning. Collectively, these results provide the most-convincing evidence to date that LTP mediates learning and memory in mammals.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for MLibrary (Deep Blue)
    Loading ...
    Support Center