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Trends Biochem Sci. 1999 Nov;24(11):441-5.

The PH superfold: a structural scaffold for multiple functions.

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European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209, D-690 12 Heidelberg, Germany.


Pleckstrin homology (PH) domains form a structurally conserved family that is associated with many regulatory pathways within the cell. Domains with a nearly identical fold are found in other families that share no sequence similarity, suggesting the existence of a stable PH superfold. The PH domains generally function as regulated membrane-binding modules that bind to inositol lipids and respond to upstream signals by targeting the host proteins to the correct cellular sites. The other domains with a similar fold, such as the phosphotyrosine binding domains, recognize protein ligands.

[Indexed for MEDLINE]

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