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Trends Biochem Sci. 1999 Nov;24(11):441-5.

The PH superfold: a structural scaffold for multiple functions.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209, D-690 12 Heidelberg, Germany.

Abstract

Pleckstrin homology (PH) domains form a structurally conserved family that is associated with many regulatory pathways within the cell. Domains with a nearly identical fold are found in other families that share no sequence similarity, suggesting the existence of a stable PH superfold. The PH domains generally function as regulated membrane-binding modules that bind to inositol lipids and respond to upstream signals by targeting the host proteins to the correct cellular sites. The other domains with a similar fold, such as the phosphotyrosine binding domains, recognize protein ligands.

PMID:
10542412
DOI:
10.1016/s0968-0004(99)01472-3
[Indexed for MEDLINE]

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