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Trends Biochem Sci. 1999 Nov;24(11):437-40.

The economics of ribosome biosynthesis in yeast.

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Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, Bronx, NY 10461, USA.


In a rapidly growing yeast cell, 60% of total transcription is devoted to ribosomal RNA, and 50% of RNA polymerase II transcription and 90% of mRNA splicing are devoted to ribosomal proteins (RPs). Coordinate regulation of the approximately 150 rRNA genes and 137 RP genes that make such prodigious use of resources is essential for the economy of the cell. This is entrusted to a number of signal transduction pathways that can abruptly induce or silence the ribosomal genes, leading to major implications for the expression of other genes as well.

[Indexed for MEDLINE]

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