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Nat Struct Biol. 1999 Nov;6(11):1055-61.

Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function.

Author information

1
Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, Box 36, New York, New York 10032, USA.

Abstract

Solutions to the nonlinear Poisson-Boltzmann equation were used to obtain the electrostatic potentials of RNA molecules that have known three-dimensional structures. The results are described in terms of isopotential contours and surface electrostatic potential maps. Both representations have unexpected features: 'cavities' within isopotential contours and areas of enhanced negative potential on molecular surfaces. Intriguingly, the sites of unusual electrostatic features correspond to functionally important regions, suggesting that electrostatic properties play a key role in RNA recognition and stabilization. These calculations reveal that the electrostatic potentials generated by RNA molecules have a variety of functionally important characteristics that cannot be discerned by simple visual inspection of the molecular structure.

PMID:
10542099
DOI:
10.1038/14940
[Indexed for MEDLINE]

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