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Nat Struct Biol. 1999 Nov;6(11):987-90.

Finding the right fold.

Author information

1
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112-0840, USA. goldenberg@biology.utah.edu

Abstract

Using mutational analysis, three groups have compared the transition states for the folding of two pairs of homologous proteins. The results of these studies suggest that protein folding mechanisms are conserved and are defined primarily by the overall topology of the native structures, as opposed to specific details of the interactions stabilizing these structures.

PMID:
10542081
DOI:
10.1038/14866
[Indexed for MEDLINE]

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