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Biol Cybern. 1999 Oct;81(4):359-71.

Oscillatory models of the hippocampus: a study of spatio-temporal patterns of neural activity.

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Centre for Neural and Adaptive Systems, School of Computing, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK.


Spatial patterns of theta-rhythm activity in oscillatory models of the hippocampus are studied here using canonical models for both Hodgkin's class-1 and class-2 excitable neuronal systems. Dynamics of these models are studied in both the frequency domain, to determine phase-locking patterns, and in the time domain, to determine the amplitude responses resulting from phase-locking patterns. Computer simulations presented here demonstrate that phase deviations (timings) between inputs from the medial septum and the entorhinal cortex can create spatial patterns of theta-rhythm phase-locking. In this way, we show that the timing of inputs (not only their frequencies alone) can encode specific patterns of theta-rhythm activity. This study suggests new experiments to determine temporal and spatial synchronization.

[Indexed for MEDLINE]

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