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Curr Pharm Des. 1999 Nov;5(11):929-37.

Structural and mechanistic aspects of evolution of beta-lactamases and penicillin-binding proteins.

Author information

1
Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446, USA.

Abstract

Penicillin-binding proteins (PBPs) and b-lactamases are related enzymes, the former are the targets for b-lactam antibiotics and the latter are resistance enzyme to these antibiotics. The two families of enzymes share structural topologies and certain mechanistic features. However, these classes of enzymes have diversified substantially and have broadened the reaction repertoire for their catalytic properties. This report addresses the issues of the evolution of function of these proteins.

PMID:
10539997
[Indexed for MEDLINE]

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