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Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1822-6.

Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A.

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1
Schools of Chemistry, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, England.

Abstract

The crystal structure of the tetrameric glycolytic enzyme phosphoglycerate mutase from the yeast Saccharomyces cerevisiae has been determined to 1.7 A resolution in complex with the sugar substrate. The difference map indicates that 3-phosphoglycerate is bound at the base of a 12 A cleft, positioning C2 of the substrate within 3.5 A of the primary catalytic residue, histidine 8.

PMID:
10531478
[Indexed for MEDLINE]
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