Adaptive thermogenesis: orchestrating mitochondrial biogenesis

R A Butow; E M Bahassi

doi:10.1016/S0960-9822(00)80008-1

Adaptive thermogenesis: orchestrating mitochondrial biogenesis

Curr Biol. 1999 Oct 21;9(20):R767-9. doi: 10.1016/S0960-9822(00)80008-1.

Authors

R A Butow¹, E M Bahassi

Affiliation

¹ Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235-9148, USA. butow@swmed.edu

PMID: 10531019
DOI: 10.1016/S0960-9822(00)80008-1

Abstract

The biogenesis of mitochondria requires products of the nuclear and mitochondrial genomes. Recent studies of adaptive thermogenesis have shown how mitochondrial proliferation and respiratory activity in brown fat and skeletal muscle are directed by the transcriptional coactivator PGC-1.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Adaptation, Physiological
Adipocytes / physiology
Adipose Tissue, Brown / physiology
Animals
Body Temperature Regulation / physiology
DNA Replication
DNA-Binding Proteins / genetics
DNA-Binding Proteins / physiology
Mitochondria / physiology*
Mitochondrial Proteins*
Muscle, Skeletal / physiology
Nuclear Proteins*
Transcription Factors / genetics
Transcription Factors / physiology

Substances

DNA-Binding Proteins
Mitochondrial Proteins
Nuclear Proteins
Transcription Factors
mitochondrial transcription factor A
peroxisome-proliferator-activated receptor-gamma coactivator-1