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Curr Biol. 1999 Oct 7;9(19):R742-6.

SWItched-on mobility.

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  • 1Laboratory of Molecular Embryology National Institute of Child Health and Human Development National Institutes of Health Building 18T, Room 106, Bethesda, Maryland, 20892-5431, USA.


Recent studies have shown that two nucleosome-remodeling complexes, NURF and CHRAC, open chromatin for transcription and replication by using their common catalytic subunit, the nucleosomal ATPase ISWI, to increase the mobility of nucleosomes relative to DNA sequence.

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