Format

Send to

Choose Destination
Cell Signal. 1999 Sep;11(9):637-50.

The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling.

Author information

1
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. tmustelin@skcc.org

Abstract

Recent years have seen an exponentially increasing interest in the molecular mechanisms of signal transduction. Much of the focus has been on protein tyrosine kinase-mediated signalling, while the study of protein tyrosine phosphatases has lagged behind. We predict that the phosphatases will become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the-art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in T lymphocyte activation.

PMID:
10530872
DOI:
10.1016/s0898-6568(99)00016-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center