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Mol Biol (Mosk). 1976 Nov-Dec;10(6):1296-302.

[Integration and transfection of an arbovirus by mammalian cells].

[Article in Russian]


A system: L cells chronically infected with Sindbis virus was studied. Unlike acute infection wherein the mature virions are produced, the chronically infected tissue culture produces subviral structures-infectious ribonucleoproteins. Molecular hybridization experiments revealed the integration of the viral genome (DNA-transcript) into the cellular genome. Transfection experiments showed the possibility to induce the synthesis of the virus in sensitive cells treated with DNA from the chronically infected cells.

[Indexed for MEDLINE]

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