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Neuropharmacology. 1999 Oct;38(10):1431-76.

Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

Author information

1
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. schoepp_darryle_d@lilly.com

Abstract

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles and involvement of mGlu receptor subtypes in physiological/pathophysiological functions of the central nervous system has been recently propelled by the emergence of various structurally novel, potent, and mGlu receptor selective pharmacological agents. This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents.

PMID:
10530808
DOI:
10.1016/s0028-3908(99)00092-1
[Indexed for MEDLINE]

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