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Trends Plant Sci. 1999 Nov;4(11):424-428.

Gibberellin signal transduction presents ellipsisthe SPY who O-GlcNAc'd me.

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Dept of Plant Biology, University of Minnesota, St Paul, MN 55108-1095, USA.


Although the molecular mechanisms by which plants respond to gibberellins are largely unknown, several components of the signal transduction pathway have been identified and a broad outline of how these components act in signal transduction is emerging. One component of the pathway, SPINDLY, is believed to be an O-GlcNAc transferase that post-translationally modifies cytosolic and nuclear proteins by the addition of O-linked N-acetylglucosamine. Although analysis of the properties of O-GlcNAc-modified proteins from animals has led to the hypothesis that this modification is regulatory, it has not been linked to specific signal transduction pathways.

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