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Biochem Biophys Res Commun. 1999 Oct 14;264(1):14-8.

Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM.

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Department of Medicine, Jichi Medical School, Kawachi-gun, Tochigi-ken, Japan.


A novel variant cDNA from the human ST2 gene other than ST2 or ST2L was identified and tentatively named ST2V. Alternative splicing inserts a new exon which leads to a change in the C-terminal portion of ST2, causing it to gain a hydrophobic tail instead of losing the third immunoglobulin-like domain. ST2V is expressed in human leukemic cell line UT-7 and its sublines UT-7/GM, UT-7/EPO, and UT-7/TPO, in addition to human helper T cell line 5C10. The amount of ST2V mRNA is greatly diminished when UT-7/GM cells are induced to differentiate into either erythroblastic or megakaryoblastic phenotypes. The possible roles of the ST2V in growth and differentiation are intriguing.

[Indexed for MEDLINE]

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