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Intern Med. 1999 Oct;38(10):759-65.

Immunopathology of ANCA-associated vasculitis.

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1
Rheumaklinik Bad Bramstedt.

Abstract

During the past few years remarkable progress has been achieved in the understanding of the pathogenic mechanisms leading to vascular inflammation and injury in ANCA-associated vasulitides (AAV): Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg Strauss syndrome (CSS). In this paper we review the immunopathology of these diseases by describing the role of autoantibodies (ANCA), dysregulation and abnormalities at the cellular level, genetic background and environmental factors that predispose to autoimmune response.

PMID:
10526937
[Indexed for MEDLINE]
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