Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 1999 Oct 18;1441(1):1-3.

Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice.

Author information

Department of Bacteriology, National Institute of Infectious Diseases (Former National Institute of Health), 1-23-1, Toyama, Shinjuku-ku, Tokyo, Japan.


We used the knockout mice lacking gangliosides and evaluated their response to tetanus and botulinum toxins. We found that tetanus toxin and botulinum type A or B toxin was less toxic in the knockout mice. We conclude that the toxins bind to the gangliosides on the synapses in the initial step of intoxication prior to penetration of the toxins into the neural cells.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center