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FEBS Lett. 1999 Oct 15;459(3):323-6.

Loss of STAT1 expression confers resistance to IFN-gamma-induced apoptosis in ME180 cells.

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Department of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Dr., Stanford, CA 94305-5236, USA.


Interferon gamma (IFN-gamma) induces apoptosis in many tumor cell lines and sensitizes tumor cells to apoptosis by tumor necrosis factor family members. IFN-gamma induces the expression of many early response genes such as interferon regulatory factor-1 (IRF-1) by activation of signal transducer and activator of transcription (STAT) factor proteins. We found that ME180 cells became resistant to IFN-gamma-induced cell death after 4-5 passages in culture. These resistant cells were characterized by a loss of STAT1 expression and a loss of inducible IRF-1 expression. We describe for the first time the emergence of a STAT1-deficient ME180 cell line.

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