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Bioorg Med Chem Lett. 1999 Oct 4;9(19):2887-92.

The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors.

Author information

1
British Biotech Pharmaceuticals Limited, Cowley, Oxford. martinf@britbio.co.uk

Abstract

Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituents. Compounds (9f, 9q) are potent selective collagenase inhibitors with good oral bioavailability.

PMID:
10522712
DOI:
10.1016/s0960-894x(99)00494-1
[Indexed for MEDLINE]

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