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Bioorg Med Chem Lett. 1999 Oct 4;9(19):2859-62.

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

Author information

1
SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK. Richard_L_Jarvest@sbphrd.com

Abstract

Tyrosyl aryl dipeptide inhibitors of S. aureus tyrosyl tRNA synthetase have been identified with IC50 values down to 0.5 microM. A crystal structure of the enzyme complexed to one of the inhibitors shows occupancy of the tyrosyl binding pocket coupled with inhibitor interactions to key catalytic residues.

PMID:
10522706
DOI:
10.1016/s0960-894x(99)00488-6
[Indexed for MEDLINE]

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