Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors

Y Zhang; D Li; J C Houtman; D T Witiak; J Seltzer; P J Bertics; C T Lauhon

doi:10.1016/s0960-894x(99)00498-9

Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2823-6. doi: 10.1016/s0960-894x(99)00498-9.

Authors

Y Zhang¹, D Li, J C Houtman, D T Witiak, J Seltzer, P J Bertics, C T Lauhon

Affiliation

¹ Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, 53706, USA.

PMID: 10522699
DOI: 10.1016/s0960-894x(99)00498-9

Abstract

A novel series of hydroxamate/urea-based inhibitors of gelatinases has been discovered via solid-phase combinatorial chemistry. SAR of P1', P2', and P3' has been exploited and structures different from traditional succinate-based MMP inhibitors have been found.

MeSH terms

Drug Design
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Hydroxamic Acids / chemical synthesis
Hydroxamic Acids / pharmacology
Matrix Metalloproteinase Inhibitors*
Molecular Structure
Urea / analogs & derivatives*

Substances

Enzyme Inhibitors
Hydroxamic Acids
Matrix Metalloproteinase Inhibitors
Urea