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Bioorg Med Chem Lett. 1999 Oct 4;9(19):2811-4.

Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.

Author information

1
Gilead Sciences Inc., Foster City, CA 94404, USA.

Abstract

The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported.

PMID:
10522696
DOI:
10.1016/s0960-894x(99)00479-5
[Indexed for MEDLINE]

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