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Bioorg Med Chem Lett. 1999 Oct 4;9(19):2795-800.

Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors.

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1
Life Sciences Division, Korea Institute of Science and Technology, Seoul.

Abstract

A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors.

PMID:
10522693
DOI:
10.1016/s0960-894x(99)00477-1
[Indexed for MEDLINE]

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