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Brain Res Mol Brain Res. 1999 Aug 25;71(2):349-53.

Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C).

Author information

1
Centro de Memória, Departamento de Bioquímica, ICBS, UFRGS (Campus da Saúde), Porto Alegre, Brazil. roesler@vortex.ufrgs.br

Abstract

Prions are the causative agents of transmissible spongiform encephalopathies. The transmissible agent (PrP(Sc)) is an abnormal form of PrP(C), a normal neuronal protein. The physiological role of PrP(C) remains unclear. In the present report, we evaluated behavioral parameters in Prnp(0/0) mice devoid of PrP(C). Prnp(0/0) mice showed normal short- and long-term retention of a step-down inhibitory avoidance task and normal behavior in an elevated plus maze test of anxiety. During a 5-min exploration of an open field, Prnp(0/0) mice showed normal number of rearings, defecation, and latency to initiate locomotion, but a significant increase in the number of crossings. The results suggest that Prnp(0/0) mice show normal fear-motivated memory, anxiety and exploratory behavior, and a slight increase in locomotor activity during exploration of a novel environment.

PMID:
10521590
DOI:
10.1016/s0169-328x(99)00193-x
[Indexed for MEDLINE]

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