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J Biol Chem. 1999 Oct 22;274(43):30764-9.

Presenilin 1 protein directly interacts with Bcl-2.

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Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro S. Giovanni di Dio, Neurobiology Laboratory, Alzheimer's Disease Unit, Via Pilastroni 4, 25123 Brescia, Italy.


Presenilin proteins are involved in familial Alzheimer's disease, a neurodegenerative disorder characterized by massive death of neurons. We describe a direct interaction between presenilin 1 (PS1) and Bcl-2, a key factor in the regulation of apoptosis, by yeast two-hybrid interaction system, by co-immunoprecipitation, and by cross-linking experiments. Our data show that PS1 and Bcl-2 assemble into a macromolecular complex, and that they are released from this complex in response to an apoptotic stimulus induced by staurosporine. The results support the idea of cross-talk between these two proteins during apoptosis.

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