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BMJ. 1999 Oct 16;319(7216):1040-4.

Is Helicobacter pylori associated with non-ulcer dyspepsia and will eradication improve symptoms? A meta-analysis.

Author information

1
Institute for Clinical Evaluative Sciences, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada M4N 3M5. liisa.jaakkimainen@ices.on.ca

Abstract

OBJECTIVES:

To examine the association between Helicobacter pylori infection and non-ulcer dyspepsia, and to assess the effect of eradicating H pylori on dyspeptic symptoms in patients with non-ulcer dyspepsia.

DESIGN:

Systematic review and meta-analysis of (a) observational studies examining the association between Helicobacter pylori infection and non-ulcer dyspepsia (association studies), and (b) therapeutic trials examining the association between eradication of H pylori and dyspeptic symptoms in patients with non-ulcer dyspepsia (eradication trials).

DATA SOURCES:

Randomised controlled trials and observational studies conducted worldwide and published between January 1983 and March 1999.

MAIN OUTCOME MEASURES:

Summary odds ratios and summary symptom scores.

RESULTS:

23 association studies and 5 eradication trials met the inclusion criteria. In the association studies the summary odds ratio for H pylori infection in patients with non-ulcer dyspepsia was 1.6 (95% confidence interval 1.4 to 1.8). In the eradication trials the summary odds ratio for improvement in dyspeptic symptoms in patients with non-ulcer dyspepsia in whom H pylori was eradicated was 1.9 (1.3 to 2.6).

CONCLUSIONS:

Some evidence shows an association between H pylori infection and dyspeptic symptoms in patients referred to gastroenterologists. An improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom H pylori was eradicated.

PMID:
10521198
PMCID:
PMC28257
DOI:
10.1136/bmj.319.7216.1040
[Indexed for MEDLINE]
Free PMC Article

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