Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Mol Life Sci. 1999 Aug 30;55(11):1386-98.

Postembryonic sensory axon guidance in Drosophila.

Author information

1
Instituto de Neurociencias, CSIC/UMH, Facultad de Medicina, Universidad Miguel Hernández, Alicante, Spain. lgalonso@umh.es

Abstract

The peripheral sensory system of the Drosophila adult has been used for the genetic analysis of axon guidance because of its accessibility for experimental manipulation and mutant screens. Wing, leg, antenna, or eye sensory axons are able to pathfind normally under different perturbations, indicating that sensory axon guidance is a highly canalized process. Similarly to other model systems, sensory growth cones seem to use multiple, simultaneous cues for guidance. In addition, sensory axons from peripheral structures seem to be capable of using alternative substrates for pathfinding. Developmental regulation could account for the high stability of axon guidance under experimental and natural perturbation conditions. Despite this flexibility, functional characterization of genes involved in sensory axon guidance is being carried out in situations where there appears to be less system redundancy.

PMID:
10518988
DOI:
10.1007/s000180050379
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center