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J Pediatr. 1999 Oct;135(4):517-21.

Characterization of esophageal body and lower esophageal sphincter motor function in the very premature neonate.

Author information

1
Gastroenterology Unit, Women's and Children's Hospital, North Adelaide, Australia.

Abstract

OBJECTIVES:

To characterize esophageal body and lower esophageal sphincter (LES) motor function in very premature infants.

STUDY DESIGN:

Esophageal manometry was performed in 12 very premature infants of 26 to 33 weeks' postmenstrual age (PMA) (body weights of 610-1360 g). Esophageal motor patterns were recorded for 30 minutes with a perfused micromanometric sleeve assembly (outer diameter, 2.0 mm).

RESULTS:

Esophageal pressure waves triggered by dry swallows were predominantly (84%) peristaltic in propagation sequence. All infants showed tonic LES contraction; the mean resting LES pressure (LESP) for individual infants ranged from 5.0 +/- 4.1 mm Hg to 20.0 +/- 4.8 mm Hg. In all infants the LES relaxed (duration, 5.8 +/- 3.0 seconds; nadir pressure, 1.8 +/- 2.6 mm Hg) in response to pharyngeal swallows. Transient LES relaxations (TLESRs) (duration, 21.7 +/- 8.7 seconds; nadir pressure, 0.1 +/- 1.8 mm Hg) occurred on average 2.6 +/- 1.6 times per study; 86% of these relaxations triggered esophageal body common cavity events known to be associated with gastroesophageal reflux.

CONCLUSIONS:

Esophageal motor function is well developed in very premature infants. Our data also suggest that TLESR is the predominant mechanism of reflux in these babies.

PMID:
10518089
DOI:
10.1016/s0022-3476(99)70178-2
[Indexed for MEDLINE]

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