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J Pept Res. 1999 Sep;54(3):206-17.

The twists and turns of beta-peptides.

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Department of Biochemistry and Biophysics, Johnson Research Foundation, School of Medicine, The University of Pennsylvania, Philadelphia 19104-6059, USA.


Recently, it has been discovered that peptides composed of beta-amino acids are capable of adopting novel secondary structures demonstrating that peptides composed of alpha-amino acids are not unique in their ability to fold into well-defined structures. Cyclic as well as acyclic peptides composed of beta-amino acid residues adopt turn, helical, and sheet-like conformations. Here, we discuss the synthesis and conformational preferences of individual, substituted beta-amino acids as well as the structures that peptides composed of these residues, beta-peptides, may adopt.

[Indexed for MEDLINE]

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