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Eur Urol. 1999 Nov;36(5):386-92.

Transurethral resection and surveillance of bladder cancer supported by 5-aminolevulinic acid-induced fluorescence endoscopy.

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1
Department of Urology, University of Munich, and Institute of Pathology, University of Regensburg, Germany. Kriegmair@uro.med.uni-muenchen.de

Abstract

PURPOSE:

We determined whether neoplastic disease, which was missed under white light can be found during transurethral resection of bladder cancer by 5-aminolevulinic acid-induced porphyrin fluorescence.

MATERIALS AND METHODS:

5-Aminolevulinic acid-induced fluorescence endoscopy was carried out in 328 cases. A 3% 5-aminolevulinic acid solution was instilled intravesically in a mean time of 2.8 h before endoscopy. The fluorescence was excited by a special incoherent light source which provided blue light in addition to white light.

RESULTS:

In 82 (25%) cases additional neoplastic lesions were found only because of their red porphyrin fluorescence which was induced by 5-aminolevulinic acid. 31% of these neoplastic foci which were found in normal and nonspecific inflamed mucosa had a poorly differentiated histology.

CONCLUSIONS:

5-Aminolevulinic acid facilitates detection of neoplastic disease during transurethral resection of bladder cancer and increases the accuracy of diagnosis.

PMID:
10516447
DOI:
20019
[Indexed for MEDLINE]
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