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Pharmacol Biochem Behav. 1999 Oct;64(2):251-6.

Arylalkylamine drugs of abuse: an overview of drug discrimination studies.

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Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond 23298-0540, USA.


Abused arylalkylamines fall into two major categories: the indolealkylamines, and the phenylalkylamines: These agents can be further subclassified on the basis of chemical structure. Examples of these agents possess hallucinogenic, stimulant, and other actions. Drug-discrimination techniques have been used to classify and investigate this large family of agents. Such studies have allowed the formulation of structure-activity relationships and investigations of mechanisms of action. Arylalkylamine designer drugs also possess the same or a combination of actions, and are being investigated by the same methods.

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