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J Antibiot (Tokyo). 1999 Jul;52(7):607-12.

TMC-66, a new endothelin converting enzyme inhibitor produced by Streptomyces sp. A5008.

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Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Saitama, Japan.


A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC50 value of 2.9 microM. Taxonomy of the producing strain is also described.

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