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Lancet. 1999 Oct 2;354(9185):1176-7.

Intoxication due to negative canrenone interference in digoxin drug monitoring.

Abstract

Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.

PMID:
10513714
DOI:
10.1016/S0140-6736(99)03818-0
[Indexed for MEDLINE]

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