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Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Jul-Aug;49(4):554-65.

[The mechanisms of memory reorganization during the retrieval of acquired behavioral experience in chicks: the effects of protein synthesis blockade in the brain].

[Article in Russian]

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Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.


It is currently assumed that disruption of memory formation by inhibitors of protein synthesis can occur in a relatively short time interval before and after training. However, there is some evidence that memory may be disrupted by delayed injections of protein synthesis inhibitors during "reminder" treatment, i.e., environmental cue that was presented earlier during the training procedure. Our experiments were conducted to test the late effects of protein synthesis inhibitor cycloheximide on memory in chicks using a reminder treatment. A standard passive avoidance task was presented to day-old chicks. A reminder (a dry bead of the same color as during training) was delivered within 2, 24, or 48 hours after the training. Chicks were bilaterally intracranially injected with cycloheximide (20 micrograms) into the IMHV area 5 min prior to reminder administration. Testing was conducted 0.5, 1, 3, 24, and 48 hours after the reminder. Administration of cycloheximide before the reminder resulted in transient amnesia. Duration of amnesia decreased with increasing interval between the training and reminder procedures. These results suggest that memory reactivated by the reminder treatment is subjected to reorganization and reconsolidation depending on protein synthesis. The gradual decrease in vulnerability of memory to protein synthesis inhibitor points to development of memory consolidation process in the interval between 2 and 48 h after training.

[Indexed for MEDLINE]

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