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Trends Biotechnol. 1999 Nov;17(11):429-36.

Knowledge discovery in gene-expression-microarray data: mining the information output of the genome.

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Incyte Pharmaceuticals, 3174 Porter Drive, Palo Alto, CA 94304, USA.


A key aspect of the genomics revolution is the transformation of large amounts of biological information into an electronic format, leading to an information-based approach to biomedical problems. Large-scale RNA assays and gene-expression-microarray studies, in particular, represent the second wave of the genomics revolution, providing gene-expression data that complement gene-sequence data and help our understanding of the molecular basis of health and disease. They are being applied at several stages in the drug-development process and could ultimately have broad applications in disease diagnosis and patient prognosis.

[Indexed for MEDLINE]

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