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Genetics. 1999 Oct;153(2):1021-7.

The detection and measurement of recombination from sequence data.

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1
School of Biological Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.

Abstract

There are two types of recombination that we may wish to detect: rare recombinants between members of different populations or species and repeated recombination within a population. Methods appropriate in the former context are inappropriate in the latter because they depend on recognizing the existence of runs of nucleotides with similar ancestry. If recombination is sufficiently frequent, no such runs will be present. Several methods, including the homoplasy test and the incompatibility test, are described that are appropriate for detecting repeated recombination and for measuring its importance, relative to mutation, in causing genetic change. The sensitivity of these tests is investigated by simulating populations with varying frequencies of mutation and recombination and calculating the various statistics on samples.

PMID:
10511575
PMCID:
PMC1460795
[Indexed for MEDLINE]
Free PMC Article
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