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J Clin Gastroenterol. 1999 Oct;29(3):277-9.

Lymph loss in the bowel and severe nutritional disturbances in Crohn's disease.

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  • 1Department of Gastroenterology, A.Z. Maria Meddelares, Gent, Belgium.

Abstract

A severe nutritional deficiency status is described in a 22-year-old patient with Crohn's disease. The clinical picture on admission was dominated by an episode of gastrointestinal bleeding secondary to clotting disturbances (vitamin K deficiency) and severe cachexia due to a protein energy malnutrition. The mechanisms of severe nutritional disturbances in Crohn's disease are multifactorial. In this patient, lymphatic leakage into the intestinal lumen was a major contributing factor in the pathogenesis of protein-losing enteropathy, fat malabsorption, and lymphocytopenia. The authors were able to demonstrate this intestinal lymph loss by nuclear imaging.

PMID:
10509957
[PubMed - indexed for MEDLINE]
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