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Bioorg Med Chem Lett. 1999 Sep 20;9(18):2747-52.

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

Author information

1
Abbott Laboratories, Abbott Park, IL 60064-3500, USA.

Abstract

Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).

PMID:
10509928
DOI:
10.1016/s0960-894x(99)00462-x
[Indexed for MEDLINE]

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